Alex K. Chen (InquilineKea)

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Radical Energy Abundance

Relevant - https://www.nytimes.com/interactive/2024/03/13/climate/electric-power-climate-change.html

Making every researcher seek grants is a broken model

Important to mention the HHMI funding model, which puts "trust" in PIs/evaluates them as PIs rather than as research proposals.

Also

"The MacArthur grant is a template for what this looks like on a personal level, with a shift in focus from creativity to integrity, and a bump in compensation – $625,000 is a lot of money, but that money is designed to be seed money for an activity rather than financial security. Those getting a MacArthur grant still face the specter of future financial needs. One needs an order of magnitude more than that over a lifetime to be secure while not compromising one’s interactions with society. "

Alex K. Chen (InquilineKea)'s Shortform

https://titotal.substack.com/p/bandgaps-brains-and-bioweapons-the

Why you, personally, should want a larger human population

I'm only comfortable with more humans if we make serious efforts to increase the percent of vegans/vegetarians, or reduce the amount of meat needed by human, given how wasteful meat is to land use.

maybe, just maybe, cultured meat will come just enough time to save us. But the probability range of this is still too high for comfort.

I very strongly believe any pro-fertility incentives must be coupled with incentives to decrease meat consumption/increase vegetarianism (or increase % of power from nuclear, given that excess solar energy will also destroy habitat).

EO Wilson once advocated that 50% of the world is set aside for wilderness. Maybe that's a bit too ambitious, but I think 35% would be good enough to preserve enough biodiversity. Taiwan/Hong Kong/Japan are all densely populated and have roughly that % of wilderness/forest (they also rely a lot on seafood, which does not destroy wilderness , but is still inherently a limited resource given overfishing)

https://www.pnas.org/doi/10.1073/pnas.2204892120 is one of the most depressing findings ever.

Alex K. Chen (InquilineKea)'s Shortform

How do you optimize your life for serendipity?

Ken Stanley has a new social network and I asked the question here: https://app.heymaven.com/discover/25623

But progress studies forum should have more people who can answer this (esp b/c serendipity and progress are both close allies)

First Nations Special Economic Zones

Tribal-based SEZs could be the perfect place for people to sell normally Rx-based drugs OTC.

On reservation land, there is already massive distrust of the "process of modern medicine" (including doctors), which prevents many people from getting the care they need. Diabetes rates (and "addiction rates") on reservations are ultra-high (one Oglala reservation featured  by Peter Santenello [he showcases the differences between Indian reservations on his YouTube videos] had dialysis centers). If diabetes medication  [eg empagliflozin, sotagliflozin, metformin, rapamycin, semaglutide]+statins+[potentially revolutionary treatments to addiction, which could include some native-based psychedelic plants] could be made OTC (OTC means trusting the customer, it means being pro-choice), it could do a lot to prevent health problems from turning into health disasters, especially on tribal lands. And since there is also substantial demand for these medications OTC among the ordinary population, it could serve as a huge source of taxable income, kind of like the casinos. 

It's already possible to get many of these Rx-based drugs OTC in Latin America (and perhaps from India/Turkey through the grey market) [Latin America has its own unique issues with high diabetes rates], but then one has to deal with inconvenient flights [or travel costs]/customs/etc, which massively reduces their convenience.
 

Similarly, they can be places where people base experimental medical treatments like exosomes or stem cell treatments (where it's a massive hassle to offer them in the US due to regulation, and where it's possible to get them in Latin America). Eg https://garmclinic.com/ (which is in Honduras, and thus tough to get to for most Americans). Any form of non-mainstream medication innovation (that the FDA holds back!) would have a strong argument for being more-than-welcome on tribal land

I've visited Roatan before, and the amount of land needed to set up these jurisdictions is quite small. If Minicircle could be offered on tribal land rather than Latin America. Of course, one would have to do due justice to issues that Native Americans face, but bypassing the untrustworthy "white man/FDA" medical system is, I think, enough of a good reason.

[OTC removes many barriers that indigeneous/poor populations face when getting the medication they need, especially preventatively.]

Upon looking further: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/cpg-sec-100350-fda-jurisdiction-indian-reservations might be an obstacle.. (it might not be impossible to change this in the name of generally increasing tribal soverignty...)

https://www.foodsafetynews.com/2013/09/not-ready-fsma-and-fdas-proposed-safety-rules-disregard-sovereignty-and-federal-case-law/

AMA: Ben Reinhardt, Speculative Technologies

Is Speculative Technologies part of the upstream process of creating alternatives to plastics? (alternatives that don't have the "persistent pollutant" or microplastic/nanoplastic decomposition problems)

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